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Cajun Roast Beef Po Boy

[heart_this] · Feb 8, 2024 · 1 Comment

Cajun Roast Beef Po Boy

Moist and tender, cajun seasoned, roast beef in hoagies; pure comfort food!

Roast beef and pot roast are some of my favourite comfort foods and this cajun inspired roast beef has been on my meal plan a lot lately! This roast beef is as easy as coating beef roast with cajun seasoning before browning it and throwing it into a slow cooker with some liquids to make the gravy! Beef broth forms the base of the gravy and it’s seasoned with worcestershire sauce and more cajun seasoning; when the beef is done cooking the liquids are transferred to a pan where cornstarch is added to thicken it up as it simmers. You can serve this cajun pot roast over mashed potatoes, rice, pasta, or in a bun, aka a po boy! I like to keep these po boys simple with buns, roast beef and gravy, mayo, lettuce, tomato, pickles and a hit of hot sauce! yum! These cajun roast beef po boys are great any time, especially for watching the game or celebrating Mardi Gras!

Cajun Roast Beef Po Boy

Cajun Roast Beef Po Boy

Cajun Roast Beef Po Boy

Cajun Roast Beef Po Boy

Cajun Roast Beef

Cajun Roast Beef Po Boy
Cajun Roast Beef Po Boy

Cajun Roast Beef Po Boy

Prep Time: 10 minutes Cook Time: 8 hours 10 minutes Total Time: 8 hours 20 minutes Servings: 6

Moist and tender, cajun seasoned, roast beef in hoagies; pure comfort food!

ingredients
  • 1 tablespoon oil
  • 1 (2-3 pound) beef roast (such as chuck, eye of round, etc.)
  • 1 tablespoon cajun seasoning (link)
  • 1 onion, sliced or diced
  • 1 or 2 cups beef broth*
  • 1 tablespoon worcestershire sauce (gluten-free for gluten-free)
  • 1 tablespoon cajun seasoning (link)
  • 1 tablespoon cornstarch
  • 1 tablespoon water
  • 6 (12 inch) hoagies/buns
  • 6 tablespoons mayonnaise
  • 2 cups lettuce, shredded
  • 2 large tomatoes, thinly sliced
  • 1/2 cup pickles, sliced
directions
  1. Heat the oil in a large oven safe pan over medium-high heat, add the beef, seasoned with the cajun seasoning, and brown on all sides, before adding the onions, broth, worcestershire sauce, and cajun seasoning.
  2. Either: (1) bring to a boil, reduce the heat to low and simmer, covered, until the beef is falling apart tender, about 2-4 hours; OR (2) cover, transfer to a preheated to 275F/140C oven and cook until falling apart tender, about 2-4 hours; OR (3) transfer to a slow cooker and cook on LOW for 8-10 hours or on HIGH for 4-6 hours.
  3. Remove the beef and shred.
  4. Bring the liquids to a boil, add the cornstarch mixed into the water, reduce the heat and simmer until the gravy thickens, about 2-3 minutes, before mixing with the beef.
  5. Assemble the po boys and enjoy!
Option: * Use 1 cup of broth for the slow cooker and 2 cups for the stovetop or oven cooking methods.
Option: If using a slow cooker, you can skip step 1 and just place everything into the slow cooker!
Option: Add 1 tablespoon soy sauce to the slow cooker along with the worcestershire sauce.
Option: Add hot sauce to the po boy’s!
Nutrition Facts: Calories 546, Fat 38g (Saturated 11g, Trans 0), Cholesterol 144mg, Sodium 519mg, Carbs 29g (Fiber 2g, Sugars 6g), Protein 44g

Nutrition by: Nutritional facts powered by Edamam
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American, Beef, Cajun and Creole, Crockpot, Food, Gluten-free, Main Course, Recipe, Slow Cooker, Southern

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Reader Interactions

Comments

  1. Mike says

    November 21, 2025 at 5:14 pm

    Never skip the sear on beef, even if going in the slow cooker. you want that extra layer of flavor

    Reply

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Kevin: I came to realize that my meals were boring and that I had been eating the same few dishes over and over again for years. It was time for a change! I now spend my free time searching for, creating and trying tasty new recipes in my closet sized kitchen.
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